April 2018 - Compounding News - Inositol
Inositol - fertility, metabolic syndrome and anxiety
Inositol is a naturally occurring sugar alcohol that is consumed in the diet, or can be produced in the body from glucose. Dietary sources include fruits, nuts, grains and beans. In grains and beans inositol is bound to phosphates, forming phytic acid. These foods must therefore be soaked, sprouted or fermented to break down the phytic acid and release the inositol. Inositol has 9 different isomers, the most common in nature is myo-inositol.
- Inositol is a component of phospholipids, so is therefore essential in the process of building cell membranes.
- It is the precursor of inositol triphosphate, a secondary messenger involved in the regulation of hormones such as TSH, FSH and insulin.
- management of intracellular calcium through the inostiol triphosphate receptors.
- Metabolic Syndrome - Inositol is used to improve the markers of metabolic syndrome, as it increases the action of insulin. A clinical trial of 80 women, published in Menopause in 2011, showed that inositol (2g twice daily) reduced blood pressure by 11%, insulin resistance by 75%, triglycerides by 20% and increased HDL cholesterol by 22%.
- PCOS – due to its effect on insulin and FSH, inositol induces ovulation, improves egg quality and increases pregnancy rates. A study of 50 anovulatory women treated with myo inositol for 3 cycles resulted in ovulation in 29 women (62%).
- Hypothyroidism – inositol influences the action of TSH and therefore has been shown to reduce TSH closer to physiological levels in patients with sub clinical hypothyroidism.
- Panic disorder – inositol has been shown to be as effective as fluvoxamine for the treatment of panic attacks, with significantly fewer side effects. The mode of action of this effect is unclear, but may involve inositol’s role in calcium release, fat transportation, nerve cell signalling or modification of serotonin release.
Clinical trial doses range from 2-18g per day in 2 divided doses, so I would recommend starting with 2g per day and titrating up according to response. Please ask us if you would like some more information about inositol or if you have any other questions about compounding.